Is your MIDI dead? You might have just used Migration Assistant to move from one computer to another. Or perhaps you upgraded to Leopard. Symptoms include:
- Can’t launch programs that use midi
- Can’t open Audio Midi setup utility or the Midi portion won’t launch or jams
- Getting messages telling you to update or reinstall your drivers
- Getting messages telling you that Midi Server won’t launch
- Core Midi doesn’t run
Believe it or not, this is sometimes caused by the Pace Interlok extensions or drivers. You can first try updating them here. If that doesn’t work, then opening terminal and entering this command should remedy the problem:
sudo rm -rf /Library/Audio/MIDI\ Drivers/*
You’ll have to enter your administrator password. This problem had vexed me for a few months, effectively disabling Core Midi - first after having run migration assistant, and again after upgrading to Leopard. I finally fixed it yesterday and can now run midi again. I hope this info will help others who are searching for a solution. I have added some distinct keywords to this message to make searching easier.
Note: If the above does not work, you need to make sure the directory below is empty, before you reinstall your interfaces. The location must be correct with no alternate spellings. It should also be ok to remove the drivers manually (by sending them to the trash), but the Terminal command helps in that regard.

Location of Midi drivers
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Thank you so much for this! A real help!
-Heebie